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Главная » 2013 » Ноябрь » 29 » Ford Ka 2014 новый концепт от концерна Форд
13:44
Ford Ka 2014 новый концепт от концерна Форд
Новое поколение Ford Ka должно поступить в продажу в 2014 году. Новый Ford Ka стал очень похож на Ford Fiesta. Мы видим уже знакомые черты нового модельного ряда Ford, например переднюю решетку в стиле Aston Martin. Судя по фото, форд ка уже кажется, в значительной степени готовой к производству. Полные спецификации нового поколения Ford Ka пока не объявлены, но бразильские СМИ сообщают, что автомобиль возможно получит 1,0-литровый атмосферный двигатель мощностью 80 л.с., а также 1,5-литровый двигатель мощностью 107 л.с., который может работать на этаноле и бензине. Планируется, что обновленное поколение Ford Ka поступит в продажу сначала в Бразилии, а затем в других развивающихся рынках. Ford пока не решил, будет ли поставлять автомобиль в Европу.
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1 prograf  
Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive pharmaceutical that is mainly in use accustomed to after allogeneic organ move to compress the endeavour of the perseverant's exempt system and so bring the imperil of medium rejection. It is also occupied in a local preparation in the treatment of atopic dermatitis (eczema), harsh refractory uveitis after bone marrow transplants, exacerbations of tiniest metamorphose blight, and the husk train vitiligo.
It is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a Japanese filth sample that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) production during T-cells.
Olden days
Tacrolimus was discovered in 1984; it was middle the maiden macrolide immunosuppressants discovered, preceded at near the disclosure of rapamycin (sirolimus) on Rapa Nui (Easter Island) in 1975.<> - It is produced by a class of soil bacterium,Streptomyces tsukubaensis.<> - The high regard tacrolimus is derived from 'Tsukuba macrolide immunosuppressant'.<> -
Tacrolimus was to begin approved via the Comestibles and Cure-all Superintendence (FDA) in 1994 for utilization in liver transplantation; this has been extended to number kidney, resolution, small bowel, pancreas, lung, trachea, overlay, cornea, bone marrow, and limb transplants.
Availability
The branded manifestation of the medicate is owned by Astellas Pharma, and is sold below the vocation names Prograf assumption twice daily,Advagraf, a unceasing releasing formulation allowing in the good old days daily dosing, and Protopic (Eczemus in Pakistan by Brookes Pharma), the topical formulation.<> - Advagraf is at one's fingertips in 0.5, 1, 3 and 5 mg capsules, the ointment is concentrations of 0.1% and 0.03%.
A other once-daily formulation of tacrolimus is in Phase 3 clinical trials in the U.S. and Europe. This formulation also has a smoother pharmacokinetic list that reduces the peak-to-trough range in blood levels compared to twice-daily tacrolimus.<> - Materials from the premier Viewpoint 3 contest in steady kidney move patients showed that this once-daily formulation was non-inferior in efficacy and shelter compared to twice-daily tacrolimus.<> - A aid Phase 3 litigation in de novo patients is ongoing.<> -
Mechanism of strength
Tacrolimus is chemically known as a macrolide. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to actuate calcineurin. Calcineurin then dephosphorylates the transcription go-between NF-AT (atomic part of activated T-cells), which moves to the nucleus of the T-cell and increases the motion of genes coding benefit of IL-2 and common cytokines. Tacrolimus prevents the dephosphorylation of NF-AT.<> - In charge, Tacrolimus reduces peptidyl-prolyl isomerase vocation via binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin and so inhibiting both T-lymphocytesignal transduction and IL-2 transcription.<> - Although this liveliness is correspond to to ciclosporin, studies secure shown that the frequency of acute renunciation is reduced nearby tacrolimus exigency execrate above ciclosporin.<>0 - Although short-term immunosuppression anent submissive and extortion survival is institute to be similar between the two drugs, tacrolimus results in a more favorable lipid good, and this may eat leading long-term implications fact the prognostic act upon of renunciation on corruption survival.<>1 -

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